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Some loss of reaction to the effects of benzodiazepines may perhaps acquire just after repeated utilization of Valium for a protracted time.apalutamide will decrease the extent or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with m